Mesenchymal stem cells (MSC) are multipotent stem cells with a great capacity for self-renewal while maintaining their multi-potency. They can develop into specialized cells of the body such as chondrocytes, osteoblasts and adipocytes. MSCs can also differentiate into nerve cells, heart muscle cells, liver cells and endothelial cells. Their easy accessibility, exceptional genomic stability, and their capacity for tissue repair with few immunological and ethical issues make them the favorable cell type for experimental and clinical use. Many trials are underway using these cells to understand and treat osteoarthritis, sepsis, autoimmune diseases, graft versus host disease, Crohn’s disease, multiple sclerosis, systemic lupus erythematosus and systemic sclerosis.
These bone marrow-derived stem cells from JangoCell are mesenchymal stem cells isolated from a neonatal (day 0) female Beagle dog leg bone. These cells are cultured, passaged for purity, cryopreserved and delivered frozen. Each vial contains >1 x 10^6 cells in 1 ml volume. Cells are characterized by flow cytometry with antibodies to CD90, CD45, and CD34 and are negative for mycoplasma, yeast, fungi, and bacteria. Cells are assured to further culture using the protocol provided by JangoCell.